Trifluoroacetic acid → HCID 67280477, compound

Participants

Reaction Steps

TFA (14.8 g, 10 mL, 130 mmol) was added to [6-(4-chloro-phenyl)-5-cyclopropylmethoxy-pyrazin-2-yl]-carbamic acid tert-butyl ester (example 50b, 1.365 g, 3.63 mmol). The resulting yellow solution was stirred at room temperature for 1 h. The solvent was evaporated and the residue was partitioned between ethyl acetate and 1M Na2CO3 solution; the organic phases were combined, dried with MgSO4 and concentrated in vacuo. The crude material was purified by flash chromatography (silica gel, 100g, 10% to 50% ethyl acetate in heptane; then ethyl acetate/methanol 9/1 to give 0.133 g (13%) of the title compound (by rearrangement) as yellow oil; MS (EI) 276.1 (M+H)+.

Provenance & Evidence