3-Pyridinecarbonyl chloride, hydrochloride (1:1) → HCID 56961450, compound

HRID 1958160Notes

Reaction equation

HRID 1958160 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]=[C:12]([NH2:14])[CH:11]=[N:10][C:9]=2[O:15][CH:16]2[CH2:19][CH2:18][CH2:17]2)=[CH:4][CH:3]=1.Cl.[C:21](Cl)(=[O:28])[C:22]1[CH:27]=[CH:26][CH:25]=[N:24][CH:23]=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:13]=[C:12]([NH:14][C:21](=[O:28])[C:22]3[CH:27]=[CH:26][CH:25]=[N:24][CH:23]=3)[CH:11]=[N:10][C:9]=2[O:15][CH:16]2[CH2:19][CH2:18][CH2:17]2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 884383-Pyridinecarbonyl chloride, hydrochloride (1:1)HCID 67280477HCID 67280477, compound

Product 1

HCID 56961450HCID 56961450, compound

Procedure

The title compound was synthesized in analogy to Example 48 e, using 6-(4-chloro-phenyl)-5-cyclobutoxy-pyrazin-2-ylamine (example 50c) and nicotinoyl chloride hydrochloride as starting materials; LC-MS (UV peak area/ESI) 97.4%, 381.1096 (M+H)+.

Sources & evidence

ORD record
ord-c82d9df0d3f04142b1b8dcaecbf040b5
Source dataset
uspto-grants-2013_04
Patent number
US08410107B2

Reaction notes

Loading…