Pyrimidine-5-carboxylic acid → HCID 56961454, compound

HRID 1958161Notes

Reaction equation

HRID 1958161 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]=[C:12]([NH2:14])[CH:11]=[N:10][C:9]=2[O:15][CH:16]2[CH2:19][CH2:18][CH2:17]2)=[CH:4][CH:3]=1.[N:20]1[CH:25]=[C:24]([C:26](O)=[O:27])[CH:23]=[N:22][CH:21]=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:13]=[C:12]([NH:14][C:26]([C:24]3[CH:25]=[N:20][CH:21]=[N:22][CH:23]=3)=[O:27])[CH:11]=[N:10][C:9]=2[O:15][CH:16]2[CH2:19][CH2:18][CH2:17]2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 78346Pyrimidine-5-carboxylic acidHCID 67280477HCID 67280477, compound

Product 1

HCID 56961454HCID 56961454, compound

Procedure

The title compound was synthesized in analogy to Example 42g, using 6-(4-chloro-phenyl)-5-cyclobutoxy-pyrazin-2-ylamine (example 50c) and 5-pyrimidinecarboxylic acid (CAN 4595-61-3) as starting materials; LC-MS (UV peak area/ESI) 96.3%, 482.1073 (M+H)+.

Sources & evidence

ORD record
ord-c89e505e3a9f42e8a9ec0557e21f6fef
Source dataset
uspto-grants-2013_04
Patent number
US08410107B2

Reaction notes

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