(4-Chloro-3-methylphenyl)boronic acid → HCID 56962105, compound

HRID 1958168Notes

Reaction equation

HRID 1958168 reaction equation
Br[C:2]1[CH:3]=[C:4]([NH:14][C:15]([C:17]2[C:18]([CH3:23])=[N:19][N:20]([CH3:22])[CH:21]=2)=[O:16])[CH:5]=[N:6][C:7]=1[O:8][CH2:9][C:10]([F:13])([F:12])[F:11].[Cl:24][C:25]1[CH:30]=[CH:29][C:28](B(O)O)=[CH:27][C:26]=1[CH3:34]>>[Cl:24][C:25]1[CH:30]=[CH:29][C:28]([C:2]2[CH:3]=[C:4]([NH:14][C:15]([C:17]3[C:18]([CH3:23])=[N:19][N:20]([CH3:22])[CH:21]=3)=[O:16])[CH:5]=[N:6][C:7]=2[O:8][CH2:9][C:10]([F:13])([F:12])[F:11])=[CH:27][C:26]=1[CH3:34]

Participants

3

Reactant 2

HCID 3786632(4-Chloro-3-methylphenyl)boronic acidHCID 67280819HCID 67280819, compound

Product 1

HCID 56962105HCID 56962105, compound

Procedure

The title compound was synthesized in analogy to Example 39, using 1,3-dimethyl-1H-pyrazole-4-carboxylic acid[5-bromo-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-yl]-amide (example 58 a) and B-(4-chloro-3-methylphenyl)-boronic acid (CAN 161950-10-3) as starting materials; LC-MS (UV peak area/ESI) 96.1%, 439.1154 (M+H)+.

Sources & evidence

ORD record
ord-7b9b1ca3ae80410ba8695c947c7c33e8
Source dataset
uspto-grants-2013_04
Patent number
US08410107B2

Reaction notes

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