2,4-Difluoropyridine-3-carboxylic acid → N-(5-(4-chloro-3-methylphenyl)-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)-2,4-difluoronicotinamide

HRID 1958169Notes

Reaction equation

HRID 1958169 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([NH2:20])[CH:11]=[N:12][C:13]=2[O:14][CH2:15][C:16]([F:19])([F:18])[F:17])=[CH:4][C:3]=1[CH3:21].[F:22][C:23]1[C:28]([C:29](O)=[O:30])=[C:27]([F:32])[CH:26]=[CH:25][N:24]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([NH:20][C:29](=[O:30])[C:28]3[C:27]([F:32])=[CH:26][CH:25]=[N:24][C:23]=3[F:22])[CH:11]=[N:12][C:13]=2[O:14][CH2:15][C:16]([F:17])([F:18])[F:19])=[CH:4][C:3]=1[CH3:21]

Participants

3

Reactant 2

HCID 121751252,4-Difluoropyridine-3-carboxylic acidHCID 672811395-(4-Chloro-3-methyl-phenyl)-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-ylamine

Product 1

HCID 56962106N-(5-(4-chloro-3-methylphenyl)-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)-2,4-difluoronicotinamide

Procedure

The title compound was synthesized in analogy to Example 42 g, using 5-(4-chloro-3-methyl-phenyl)-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-ylamine (example 57 a) and 2,4-difluoro-3-pyridinecarboxylic acid (CAN 849937-90-2) as starting materials; MS (EI) 458.2 (M+H)+.

Sources & evidence

ORD record
ord-8c360eefd5af4eff8e2ec257940240fa
Source dataset
uspto-grants-2013_04
Patent number
US08410107B2

Reaction notes

Loading…