(4-Chloro-3-methylphenyl)boronic acid → HCID 56962109, compound

HRID 1958172Notes

Reaction equation

HRID 1958172 reaction equation
Br[C:2]1[CH:3]=[C:4]([NH:14][C:15]([C:17]2[N:18]=[N:19][CH:20]=[CH:21][CH:22]=2)=[O:16])[CH:5]=[N:6][C:7]=1[O:8][CH2:9][C:10]([F:13])([F:12])[F:11].[Cl:23][C:24]1[CH:29]=[CH:28][C:27](B(O)O)=[CH:26][C:25]=1[CH3:33]>>[Cl:23][C:24]1[CH:29]=[CH:28][C:27]([C:2]2[CH:3]=[C:4]([NH:14][C:15]([C:17]3[N:18]=[N:19][CH:20]=[CH:21][CH:22]=3)=[O:16])[CH:5]=[N:6][C:7]=2[O:8][CH2:9][C:10]([F:13])([F:12])[F:11])=[CH:26][C:25]=1[CH3:33]

Participants

3

Reactant 2

HCID 3786632(4-Chloro-3-methylphenyl)boronic acidHCID 67280671HCID 67280671, compound

Product 1

HCID 56962109HCID 56962109, compound

Procedure

The title compound was synthesized in analogy to Example 39, using pyridazine-3-carboxylic acid[5-bromo-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-yl]-amide (example 62 a) and B-(4-chloro-3-methylphenyl)-boronic acid (CAN 161950-10-3) as starting materials; LC-MS (UV peak area/ESI) 94.2%, 423.0828 (M+H)+.

Sources & evidence

ORD record
ord-ee2cb83e6fec41bd87915e60933b0bc8
Source dataset
uspto-grants-2013_04
Patent number
US08410107B2

Reaction notes

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