2-Furancarboxylic acid → HCID 56961280, compound

HRID 1958176Notes

Reaction equation

HRID 1958176 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([NH2:20])[CH:11]=[N:12][C:13]=2[O:14][CH2:15][C:16]([F:19])([F:18])[F:17])=[CH:4][CH:3]=1.[O:21]1[CH:25]=[CH:24][CH:23]=[C:22]1[C:26](O)=[O:27]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[C:10]([NH:20][C:26]([C:22]3[O:21][CH:25]=[CH:24][CH:23]=3)=[O:27])[CH:11]=[N:12][C:13]=2[O:14][CH2:15][C:16]([F:17])([F:18])[F:19])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 69192-Furancarboxylic acidHCID 672813155-(4-Chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-ylamine

Product 1

HCID 56961280HCID 56961280, compound

Procedure

The title compound was synthesized in analogy to Example 42 g, using 5-(4-chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-ylamine (example E) and 2-furancarboxylic acid (CAN 88-14-2) as starting materials; LC-MS (UV peak area/ESI) 98.0%, 397.0566 (M+H)+.

Sources & evidence

ORD record
ord-0c7af2321a274ed8860d0ba95a0fa861
Source dataset
uspto-grants-2013_04
Patent number
US08410107B2

Reaction notes

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