2-Furancarboxylic acid, 5-methyl- → HCID 56961282, compound

HRID 1958178Notes

Reaction equation

HRID 1958178 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([NH2:20])[CH:11]=[N:12][C:13]=2[O:14][CH2:15][C:16]([F:19])([F:18])[F:17])=[CH:4][CH:3]=1.[CH3:21][C:22]1[O:26][C:25]([C:27](O)=[O:28])=[CH:24][CH:23]=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[C:10]([NH:20][C:27]([C:25]3[O:26][C:22]([CH3:21])=[CH:23][CH:24]=3)=[O:28])[CH:11]=[N:12][C:13]=2[O:14][CH2:15][C:16]([F:17])([F:18])[F:19])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 747102-Furancarboxylic acid, 5-methyl-HCID 672813155-(4-Chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-ylamine

Product 1

HCID 56961282HCID 56961282, compound

Procedure

The title compound was synthesized in analogy to Example 42 g, using 5-(4-chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-ylamine (example E) and 5-methyl-2-furancarboxylic acid (CAN 1917-15-3) as starting materials; LC-MS (UV peak area/ESI) 98.0%, 409.574 (M−H)−.

Sources & evidence

ORD record
ord-de5c97ed6e354fed94a96fbaf0b5d10f
Source dataset
uspto-grants-2013_04
Patent number
US08410107B2

Reaction notes

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