HuagongsheHuagongshe Chemistry Print Report · For research reference only
(+-)-Tetrahydro-2-furoic acid → HCID 67280372, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (+-)-Tetrahydro-2-furoic acid | HCID 86079 | — |
| Reactant | 5-(4-Chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-ylamine | HCID 67281315 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 67280372 | HCID 67280372 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 42 g, using 5-(4-chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-ylamine (example E) and tetrahydro-2-furancarboxylic acid, (CAN 16874-33-2) as starting materials; enantiomers were separated by chiral HPLC (ChiralPak AD, 30% ethanol/n-heptane (−) enantiomer isolated; LC-MS (UV peak area/ESI) 100%, 401.0868 (M+H)+; αD20 (MeOH)=−16.8°
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08410107B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-79c45529cbea4a05a56aba63742ece6f |
| Source note | uspto-grants-2013_04 |