5-Iodonicotinic acid → {2-Chloro-4-[5-[(5-iodo-pyridine-3-carbonyl)-amino]-2-(2,2,2-trifluoro-ethoxy)-pyridin-3-yl]-phenyl}-carbamic acid benzyl ester

HRID 1958186Notes

Reaction equation

HRID 1958186 reaction equation
[CH2:1]([O:8][C:9](=[O:31])[NH:10][C:11]1[CH:16]=[CH:15][C:14]([C:17]2[C:18]([O:24][CH2:25][C:26]([F:29])([F:28])[F:27])=[N:19][CH:20]=[C:21]([NH2:23])[CH:22]=2)=[CH:13][C:12]=1[Cl:30])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[I:32][C:33]1[CH:34]=[C:35]([C:39](O)=[O:40])[CH:36]=[N:37][CH:38]=1>>[CH2:1]([O:8][C:9](=[O:31])[NH:10][C:11]1[CH:16]=[CH:15][C:14]([C:17]2[C:18]([O:24][CH2:25][C:26]([F:29])([F:28])[F:27])=[N:19][CH:20]=[C:21]([NH:23][C:39]([C:35]3[CH:36]=[N:37][CH:38]=[C:33]([I:32])[CH:34]=3)=[O:40])[CH:22]=2)=[CH:13][C:12]=1[Cl:30])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 1519505-Iodonicotinic acidHCID 67280667{4-[5-Amino-2-(2,2,2-trifluoro-ethoxy)-pyridin-3-yl]-2-chloro-phenyl}-carbamic acid benzyl ester

Product 1

HCID 67282185{2-Chloro-4-[5-[(5-iodo-pyridine-3-carbonyl)-amino]-2-(2,2,2-trifluoro-ethoxy)-pyridin-3-yl]-phenyl}-carbamic acid benzyl ester

Procedure

The title compound was synthesized in analogy to Example 42 g, using {4-[5-amino-2-(2,2,2-trifluoro-ethoxy)-pyridin-3-yl]-2-chloro-phenyl}-carbamic acid benzyl ester (example 73 a) and 5-iodo-3-pyridinecarboxylic acid (CAN 15366-65-1) as starting materials; LC-MS (UV peak area/ESI) 68.6%, 683.4 (M+H)+.

Sources & evidence

ORD record
ord-3ffc0145a9eb4daba19fe0675b594e70
Source dataset
uspto-grants-2013_04
Patent number
US08410107B2

Reaction notes

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