HRID1958186

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID151950

5-Iodonicotinic acid

C6H4INO2

结构：Nc1cnc(OCC(F)(F)F)c(-c2ccc(NC(=O)OCc3ccccc3)c(Cl)c2)c1

HCID67280667

未命名化合物

PRODUCTS

生成物

结构：O=C(Nc1ccc(-c2cc(NC(=O)c3cncc(I)c3)cnc2OCC(F)(F)F)cc1Cl)OCc1ccccc1

HCID67282185

未命名化合物

PROCEDURE

实验过程

The title compound was synthesized in analogy to Example 42 g, using {4-[5-amino-2-(2,2,2-trifluoro-ethoxy)-pyridin-3-yl]-2-chloro-phenyl}-carbamic acid benzyl ester (example 73 a) and 5-iodo-3-pyridinecarboxylic acid (CAN 15366-65-1) as starting materials; LC-MS (UV peak area/ESI) 68.6%, 683.4 (M+H)+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3ffc0145a9eb4daba19fe0675b594e70
来源数据集: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08410107B2
来源说明: uspto-grants-2013_04

反应 SMILES

[CH2:1]([O:8][C:9](=[O:31])[NH:10][C:11]1[CH:16]=[CH:15][C:14]([C:17]2[C:18]([O:24][CH2:25][C:26]([F:29])([F:28])[F:27])=[N:19][CH:20]=[C:21]([NH2:23])[CH:22]=2)=[CH:13][C:12]=1[Cl:30])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[I:32][C:33]1[CH:34]=[C:35]([C:39](O)=[O:40])[CH:36]=[N:37][CH:38]=1>>[CH2:1]([O:8][C:9](=[O:31])[NH:10][C:11]1[CH:16]=[CH:15][C:14]([C:17]2[C:18]([O:24][CH2:25][C:26]([F:29])([F:28])[F:27])=[N:19][CH:20]=[C:21]([NH:23][C:39]([C:35]3[CH:36]=[N:37][CH:38]=[C:33]([I:32])[CH:34]=3)=[O:40])[CH:22]=2)=[CH:13][C:12]=1[Cl:30])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1