4-Fluorophenylboronic acid → HCID 56961999, compound

HRID 1958189Notes

Reaction equation

HRID 1958189 reaction equation
Br[C:2]1[CH:3]=[C:4]([NH:14][C:15](=[O:22])[C:16]2[CH:21]=[CH:20][CH:19]=[N:18][CH:17]=2)[CH:5]=[N:6][C:7]=1[O:8][CH2:9][C:10]([F:13])([F:12])[F:11].[F:23][C:24]1[CH:29]=[CH:28][C:27](B(O)O)=[CH:26][CH:25]=1>>[F:23][C:24]1[CH:29]=[CH:28][C:27]([C:2]2[CH:3]=[C:4]([NH:14][C:15](=[O:22])[C:16]3[CH:21]=[CH:20][CH:19]=[N:18][CH:17]=3)[CH:5]=[N:6][C:7]=2[O:8][CH2:9][C:10]([F:13])([F:12])[F:11])=[CH:26][CH:25]=1

Participants

3

Reactant 2

HCID 2856454-Fluorophenylboronic acidHCID 67280716N-(5-bromo-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)nicotinamide

Product 1

HCID 56961999HCID 56961999, compound

Procedure

The title compound was synthesized in analogy to Example 39, using N-[5-bromo-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-yl]-nicotinamide (example G) and B-(4-fluorophenyl)-boronic acid (CAN 1765-93-1) as starting materials; LC-MS (UV peak area/ESI) 100%, 392.1005 (M+H)+.

Sources & evidence

ORD record
ord-7f05f87f03b7414881b629235ff1b6e8
Source dataset
uspto-grants-2013_04
Patent number
US08410107B2

Reaction notes

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