(3-Chlorophenyl)boronic acid → HCID 56962000, compound

HRID 1958190Notes

Reaction equation

HRID 1958190 reaction equation
Br[C:2]1[CH:3]=[C:4]([NH:14][C:15](=[O:22])[C:16]2[CH:21]=[CH:20][CH:19]=[N:18][CH:17]=2)[CH:5]=[N:6][C:7]=1[O:8][CH2:9][C:10]([F:13])([F:12])[F:11].[Cl:23][C:24]1[CH:25]=[C:26](B(O)O)[CH:27]=[CH:28][CH:29]=1>>[Cl:23][C:24]1[CH:29]=[C:28]([C:2]2[CH:3]=[C:4]([NH:14][C:15](=[O:22])[C:16]3[CH:21]=[CH:20][CH:19]=[N:18][CH:17]=3)[CH:5]=[N:6][C:7]=2[O:8][CH2:9][C:10]([F:13])([F:12])[F:11])[CH:27]=[CH:26][CH:25]=1

Participants

3

Reactant 2

HCID 2734323(3-Chlorophenyl)boronic acidHCID 67280716N-(5-bromo-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)nicotinamide

Product 1

HCID 56962000HCID 56962000, compound

Procedure

The title compound was synthesized in analogy to Example 39, using N-[5-bromo-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-yl]-nicotinamide (example G) and B-(3-chlorophenyl)-boronic acid (CAN 63503-60-6) as starting materials; LC-MS (UV peak area/ESI) 100%, 408.0719 (M+H)+.

Sources & evidence

ORD record
ord-9a50d569a60c414c9af6d2b889be41ab
Source dataset
uspto-grants-2013_04
Patent number
US08410107B2

Reaction notes

Loading…