4-Methyl-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine-7-carboxylic acid → HCID 56962004, compound

HRID 1958197Notes

Reaction equation

HRID 1958197 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([NH2:20])[CH:11]=[N:12][C:13]=2[O:14][CH2:15][C:16]([F:19])([F:18])[F:17])=[CH:4][C:3]=1[CH3:21].[CH3:22][N:23]1[CH2:28][CH2:27][O:26][C:25]2[CH:29]=[C:30]([C:33](O)=[O:34])[CH:31]=[N:32][C:24]1=2>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([NH:20][C:33]([C:30]3[CH:31]=[N:32][C:24]4[N:23]([CH3:22])[CH2:28][CH2:27][O:26][C:25]=4[CH:29]=3)=[O:34])[CH:11]=[N:12][C:13]=2[O:14][CH2:15][C:16]([F:17])([F:18])[F:19])=[CH:4][C:3]=1[CH3:21]

Participants

3

Reactant 2

HCID 242296454-Methyl-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine-7-carboxylic acidHCID 67281139HCID 67281139, compound

Product 1

HCID 56962004HCID 56962004, compound

Procedure

The title compound was synthesized in analogy to Example 42 g, using 5-(4-chloro-3-methyl-phenyl)-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-ylamine (example 57 a) and 3,4-dihydro-4-methyl-2H-pyrido[3,2-b]-1,4-oxazine-7-carboxylic acid (CAN 915707-58-3) as starting materials; MS (EI) 493.1(M+H)+.

Sources & evidence

ORD record
ord-b02892d979f14caf91b7106bf8db7f85
Source dataset
uspto-grants-2013_04
Patent number
US08410107B2

Reaction notes

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