5-Bromonicotinic acid → 5-bromo-N-(5-(4-chlorophenyl)-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)nicotinamide

HRID 1958203Notes

Reaction equation

HRID 1958203 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([NH2:20])[CH:11]=[N:12][C:13]=2[O:14][CH2:15][C:16]([F:19])([F:18])[F:17])=[CH:4][CH:3]=1.[Br:21][C:22]1[CH:23]=[C:24]([C:28](O)=[O:29])[CH:25]=[N:26][CH:27]=1>>[Br:21][C:22]1[CH:27]=[N:26][CH:25]=[C:24]([CH:23]=1)[C:28]([NH:20][C:10]1[CH:11]=[N:12][C:13]([O:14][CH2:15][C:16]([F:17])([F:18])[F:19])=[C:8]([C:5]2[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=2)[CH:9]=1)=[O:29]

Participants

3

Reactant 2

HCID 887075-Bromonicotinic acidHCID 672813155-(4-Chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-ylamine

Product 1

HCID 569620555-bromo-N-(5-(4-chlorophenyl)-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)nicotinamide

Procedure

The title compound was synthesized in analogy to Example 42 g, using 5-(4-chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-ylamine (example E) and 5-bromo-3-pyridinecarboxylic acid (CAN 20826-04-4) as starting materials; LC-MS (UV peak area/ESI) 92.7%, 485.9662 (M−H)−.

Sources & evidence

ORD record
ord-99aea95b8b82485db931fa58b47af5bf
Source dataset
uspto-grants-2013_04
Patent number
US08410107B2

Reaction notes

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