5-(Ethoxycarbonyl)pyridine-3-carboxylic acid → HCID 67280736, compound

HRID 1958205Notes

Reaction equation

HRID 1958205 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([NH2:20])[CH:11]=[N:12][C:13]=2[O:14][CH2:15][C:16]([F:19])([F:18])[F:17])=[CH:4][CH:3]=1.[CH2:21]([O:23][C:24]([C:26]1[CH:27]=[N:28][CH:29]=[C:30]([C:32](O)=[O:33])[CH:31]=1)=[O:25])[CH3:22]>>[CH2:21]([O:23][C:24](=[O:25])[C:26]1[CH:31]=[C:30]([C:32](=[O:33])[NH:20][C:10]2[CH:11]=[N:12][C:13]([O:14][CH2:15][C:16]([F:17])([F:18])[F:19])=[C:8]([C:5]3[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=3)[CH:9]=2)[CH:29]=[N:28][CH:27]=1)[CH3:22]

Participants

3

Reactant 2

HCID 12144465-(Ethoxycarbonyl)pyridine-3-carboxylic acidHCID 672813155-(4-Chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-ylamine

Product 1

HCID 67280736HCID 67280736, compound

Procedure

The title compound was synthesized in analogy to Example 42 g, using 5-(4-chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-ylamine (example E) and 3,5-pyridinedicarboxylic acid 3-ethyl ester (CAN 84254-37-5) as starting materials; MS (EI) 480.1(M+H)+.

Sources & evidence

ORD record
ord-df64a051ad40481181043af61addf9c8
Source dataset
uspto-grants-2013_04
Patent number
US08410107B2

Reaction notes

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