HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methoxypropanoic acid → HCID 56962056, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methoxypropanoic acid | HCID 92209 | — |
| Reactant | 5-(4-Chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-ylamine | HCID 67281315 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 56962056 | HCID 56962056 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 42 g, using 5-(4-chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-ylamine (example E) and 2-methoxy-propanoic acid (CAN 4324-37-2) as starting materials; enantiomers were separated by chiral HPLC (ChiralPak AD, 10% ethanol/n-heptane); (+) enantiomer isolated; LC-MS (UV peak area/ESI) 100%, 389.0874 (M+H)+; αD20 (MeOH)=+37.5°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08410107B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-8e52bc090bab4a1b8d0a0f24bae369a2 |
| Source note | uspto-grants-2013_04 |