HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl piperazine-1-carboxylate → (S)-1-Boc-4-(oxiran-2-ylmethyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Reactant | Benzenesulfonic acid, 3-nitro-, (2R)-2-oxiranylmethyl ester | HCID 146513 | — |
| Product | (S)-1-Boc-4-(oxiran-2-ylmethyl)piperazine | HCID 10977626 | 70% |
Reaction Steps
The same method as employed in the preparation of Intermediate 1 but starting from piperazine-1-carboxylic acid tert-butyl ester and (R)-(−)-3-nitro-benzenesulfonic acid oxiranylmethyl ester gives after flash chromatography the title compound as a yellow oil in a 70% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08410110B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-2128c94d8fe14366b8252ff6276ebd30 |
| Source note | uspto-grants-2013_04 |