(Oxiran-2-yl)methyl 3-nitrobenzene-1-sulfonate → HCID 17810512, compound

HRID 1958276Notes

Reaction equation

HRID 1958276 reaction equation
[C:1]1([C:7]2[N:11]=[C:10]([N:12]3[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]3)[S:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[O:18]1[CH2:20][CH:19]1[CH2:21]OS(C1C=CC=C([N+]([O-])=O)C=1)(=O)=O>>[O:18]1[CH2:20][CH:19]1[CH2:21][N:15]1[CH2:16][CH2:17][N:12]([C:10]2[S:9][N:8]=[C:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[N:11]=2)[CH2:13][CH2:14]1

Participants

3

Reactant 2

HCID 286836(Oxiran-2-yl)methyl 3-nitrobenzene-1-sulfonateHCID 27777601-(3-Phenyl-(1,2,4)thiadiazol-5-yl)-piperazine

Product 1

HCID 17810512HCID 17810512, compoundYield 60%

Procedure

The same method as employed in the preparation of Intermediate 1 but starting from 1-(3-phenyl-1,2,4-thiadiazol-5-yl)-piperazine and 3-nitro-benzenesulfonic acid oxiranylmethyl ester gives after Biotage chromatography the title compound as a white powder in a 60% yield.

Sources & evidence

ORD record
ord-d5a4a7b1026e4eb594f109d217d10cbc
Source dataset
uspto-grants-2013_04
Patent number
US08410110B2

Reaction notes

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