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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1958277Generated: October 27, 2026

(Oxiran-2-yl)methyl 3-nitrobenzene-1-sulfonate → (+/-)-1-(Cyclohexylmethyl)-4-(oxiran-2-ylmethyl)piperazine

https://huagongshe.com/reaction/1958277

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(Oxiran-2-yl)methyl 3-nitrobenzene-1-sulfonateHCID 286836—
Reactant1-(Cyclohexylmethyl)piperazineHCID 2735885—
Product(+/-)-1-(Cyclohexylmethyl)-4-(oxiran-2-ylmethyl)piperazineHCID 8666198492%

Reaction Steps

The same method as employed in the preparation of Intermediate 1 but starting from 1-cyclohexylmethyl piperazine and (±)-3-nitro-benzenesulfonic acid oxiranylmethyl ester gives after flash chromatography the title compound as a yellow oil in a 92% yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08410110B2
Source datasetuspto-grants-2013_04
ORD IDord-2536eeedebbf49a0b6412589d7783b57
Source noteuspto-grants-2013_04