HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 53466710, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Acetonitrile--water (1/1) | HCID 18373917 | — |
| Reactant | 5-Ethylisoxazole-3-carbonyl chloride | HCID 20072741 | — |
| Reactant | 2-Phenylimidazo[1,2-A]pyrimidin-7-amine | HCID 50878390 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 53466710 | HCID 53466710 | 16% |
Reaction Steps
Triethylamine and 5-ethyl-isoxazole-3-carbonyl chloride were added to a solution of 2-phenyl-imidazo[1,2-a]pyrimidin-7-ylamine (example 1, step 1) in dichloromethane, and the mixture was stirred at RT overnight. The title compound (29 mg, 16%) was isolated from the mixture by preparative HPLC (254 nm, Agilent Zorbax XdB-C18, Run: 7 min, Flow: 30 ml/min, Gradient: 0.0 min: 95/5 H2O/CH3CN; 0.5 min: 95/5 H2O/CH3CN 4.5 min: 5/95 H2O/CH3CN; 6.9 min 5/95 H2O/CH3CN; 7 min 95/5 H2O/CH3CN).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08410117B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-56ed0518142c414590fadf9e6544b5ad |
| Source note | uspto-grants-2013_04 |