HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → Ethyl 5-(chlorocarbonyl)-1-methyl-1H-pyrazole-4-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 4-(Ethoxycarbonyl)-1-methyl-1H-pyrazole-5-carboxylic acid | HCID 25247567 | — |
| Product | Ethyl 5-(chlorocarbonyl)-1-methyl-1H-pyrazole-4-carboxylate | HCID 60136485 | 110.7% |
Reaction Steps
A mixture of 2-methyl-2H-pyrazole-3,4-dicarboxylic acid 4-ethyl ester (6.00 g) and thionyl chloride (82.8 g) was refluxed for 4 h. Excess thionyl chloride was removed under educed pressure; the obtained crude product (7.26 g, assumed purity ˜60%, 66%) was used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08410117B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-3d72b5ece5b24cd9bf5f677283063372 |
| Source note | uspto-grants-2013_04 |