HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1958324Generated: October 25, 2026
Furo(3,4-b)pyrazine-5,7-dione → 3-(2-Phenyl-imidazo[1,2-a]pyrimidin-7-ylcarbamoyl)-pyrazine-2-carboxylic acid
https://huagongshe.com/reaction/1958324
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Furo(3,4-b)pyrazine-5,7-dione | HCID 78482 | — |
| Reactant | 2-Phenylimidazo[1,2-A]pyrimidin-7-amine | HCID 50878390 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-(2-Phenyl-imidazo[1,2-a]pyrimidin-7-ylcarbamoyl)-pyrazine-2-carboxylic acid | HCID 67387769 | 47% |
Reaction Steps
Furo[3,4-b]pyrazine-5,7-dione (736 mg, 4.9 mmol) and DMAP (58 mg, cat.) were added to a solution of 2-phenyl-imidazo[1,2-a]pyrimidin-7-ylamine (example 1, step 1, 1.00 g, 4.8 mmol) in DMF (25 ml). The mixture was heated to 78° C. overnight, and cooled to RT. The formed precipitate was collected by filtration, and residual solvent was removed under vacuum. The thus obtained crude product (800 mg, 47%) was used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08410117B2 |
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| Source dataset | uspto-grants-2013_04 |
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| ORD ID | ord-8d4635bc6bb74226ba7ef648f8d31a82 |
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| Source note | uspto-grants-2013_04 |
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