HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → Methyl 3-(chlorocarbonyl)pyridine-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2-Methyl 2,3-pyridinedicarboxylate | HCID 98626 | — |
| Product | Methyl 3-(chlorocarbonyl)pyridine-2-carboxylate | HCID 13239660 | 112.5% |
Reaction Steps
Pyridine-2,3-dicarboxylic acid 2-methyl ester (500 mg, 2.76 mmol) was dissolved in thionyl chloride (8.21 g, 68 mmol) and heated to reflux for 4 h. Excess thionyl chloride was removed under vacuum. The obtained crude product (620 mg, assumed purity 60%, 68% yield) was used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08410117B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-7fdcd6ce251842918e4673b775f75561 |
| Source note | uspto-grants-2013_04 |