Triethylamine → HCID 67384038, compound

Participants

Reaction Steps

3-Chlorocarbonyl-pyridine-2-carboxylic acid methyl ester (620 mg, 3.1 mmol) was added slowly to a solution of 2-phenyl-imidazo[1,2-a]pyrimidin-7-ylamine (step 1, example 1, 470 mg, 2.2 mmol) and triethylamine (566 mg) in dichloromethane (7 ml), and the mixture was stirred overnight at RT. The mixture was diluted with additional dichloromethane, and washed with water. The combined organic layers were dried (Na2SO4), the solvent was evaporated, and the title compound (490 mg, 49%) was obtained from the residue by column chromatography (silica gel, dichloromethane:methanol=50:50-0:100). MS (m/e)=374.2 [M+H+].

Provenance & Evidence