Sulfuric acid magnesium salt (1:1) → HCID 67387982, compound

Participants

Reaction Steps

Trimethylaluminum (2M solution in toluene, 0.3 ml) was added to a stirred suspension of 2-phenyl-imidazo[1,2-a]pyrimidin-7-ylamine (example 1, step 1, 128 mg) in dioxane (5 ml), and the mixture was stirred for 2 h at RT. 1-Methyl-3-(pyrimidin-5-ylamino)-1H-pyrazole-4-carboxylic acid ethyl ester (50 mg) was then added in one portion, and the mixture was heated to 100° C. for 17 h. Upon cooling, water (0.5 ml) was added, followed by small amounts of methanol and dichloromethane to get an almost clear solution. Some MgSO4 was added, the mixture was stirred for 15 min, and filtered. The filtrate was concentrated, and the title compound (23 mg, 28%) was isolated from the residue by column chromatography (silica gel, dichloromethane/methanol gradient), followed by trituration (methanol).

Provenance & Evidence