1-Methyl-1H-pyrazole-4-carboxylic acid → HCID 58446859, compound

HRID 1958349Notes

Reaction equation

HRID 1958349 reaction equation
[CH3:1][N:2]1[CH:6]=[C:5]([C:7]([OH:9])=O)[CH:4]=[N:3]1.Cl.[F:11][CH:12]1[CH2:15][NH:14][CH2:13]1>>[F:11][CH:12]1[CH2:15][N:14]([C:7]([C:5]2[CH:4]=[N:3][N:2]([CH3:1])[CH:6]=2)=[O:9])[CH2:13]1

Participants

3

Reactant 2

HCID 6431601-Methyl-1H-pyrazole-4-carboxylic acidHCID 101250543-fluoroazetidine Hydrochloride

Product 1

HCID 58446859HCID 58446859, compound

Procedure

From 1-methyl-1H-pyrazole-4-carboxylic acid (1.0 g, 7.93 mmol) and 3-fluoroazetidine hydrochloride (884 mg, 7.93 mmol). Off-white solid (597 mg, 41%).

Sources & evidence

ORD record
ord-944a2030fb4b45049c286d70622e1e12
Source dataset
uspto-grants-2013_04
Patent number
US08410117B2

Reaction notes

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