HCID 58446922, compound → 4-(Azetidine-1-carbonyl)-2-methyl-2H-pyrazole-3-carboxylic acid [2-(3-fluoro-phenyl)-imidazo[1,2-a]pyrimidin-7-yl]-amide

HRID 1958353Notes

Reaction equation

HRID 1958353 reaction equation
[N:1]1([C:5]([C:7]2[CH:8]=[N:9][N:10]([CH3:15])[C:11]=2[C:12]([OH:14])=O)=[O:6])[CH2:4][CH2:3][CH2:2]1.[F:16][C:17]1[CH:18]=[C:19]([C:23]2[N:24]=[C:25]3[CH:30]=[C:29]([NH2:31])[N:28]=[CH:27][N:26]3[CH:32]=2)[CH:20]=[CH:21][CH:22]=1>>[F:16][C:17]1[CH:18]=[C:19]([C:23]2[N:24]=[C:27]3[N:28]=[C:29]([NH:31][C:12]([C:11]4[N:10]([CH3:15])[N:9]=[CH:8][C:7]=4[C:5]([N:1]4[CH2:2][CH2:3][CH2:4]4)=[O:6])=[O:14])[CH:30]=[CH:25][N:26]3[CH:32]=2)[CH:20]=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 58446922HCID 58446922, compoundHCID 673911462-(3-Fluorophenyl)imidazo[1,2-c]pyrimidin-7-amine

Product 1

HCID 534682444-(Azetidine-1-carbonyl)-2-methyl-2H-pyrazole-3-carboxylic acid [2-(3-fluoro-phenyl)-imidazo[1,2-a]pyrimidin-7-yl]-amide

Procedure

The title compound was prepared in analogy to example 82 from 4-(azetidine-1-carbonyl)-1-methyl-1H-pyrazole-5-carboxylic acid (91.7 mg, 438 μmol) and 2-(3-fluorophenyl)imidazo[1,2-c]pyrimidin-7-amine (100 mg, 438 μmol). Yellow solid (6.5 mg, 3.5%). MS (m/z)=420.1 [M+H+].

Sources & evidence

ORD record
ord-8eab6863475045eaaeed207be7196992
Source dataset
uspto-grants-2013_04
Patent number
US08410117B2

Reaction notes

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