HCID 19623797, compound → HCID 53468451, compound

HRID 1958355Notes

Reaction equation

HRID 1958355 reaction equation
[CH3:1][N:2]([CH3:14])[C:3]([C:5]1[CH:9]=[N:8][N:7]([CH3:10])[C:6]=1[C:11]([OH:13])=O)=[O:4].[NH2:15][C:16]1[CH:21]=[CH:20][N:19]2[CH:22]=[C:23]([C:25]3[CH:26]=[C:27]([O:31][C:32](=[O:34])[CH3:33])[CH:28]=[CH:29][CH:30]=3)[N:24]=[C:18]2[N:17]=1>>[C:32]([O:31][C:27]1[CH:28]=[CH:29][CH:30]=[C:25]([C:23]2[N:24]=[C:18]3[N:17]=[C:16]([NH:15][C:11]([C:6]4[N:7]([CH3:10])[N:8]=[CH:9][C:5]=4[C:3](=[O:4])[N:2]([CH3:1])[CH3:14])=[O:13])[CH:21]=[CH:20][N:19]3[CH:22]=2)[CH:26]=1)(=[O:34])[CH3:33]

Participants

3

Reactant 2

HCID 19623797HCID 19623797, compoundHCID 58446806HCID 58446806, compound

Product 1

HCID 53468451HCID 53468451, compound

Procedure

The title compound was prepared in analogy to example 82, step 3, from 4-dimethylcarbamoyl-2-methyl-2H-pyrazole-3-carboxylic acid (step 2, example 85; 44.1 mg, 224 μmol) and acetic acid 3-(7-amino-imidazo[1,2-a]pyrimidin-2-yl)-phenyl ester (50 mg, 186 μmol). Yield: 53 mg (60%). Yellow solid. MS (m/z)=448.2 [M+H+].

Sources & evidence

ORD record
ord-51cf7efaf95d45a4b40a431b52602a1d
Source dataset
uspto-grants-2013_04
Patent number
US08410117B2

Reaction notes

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