HCID 58446922, compound → HCID 53468647, compound

HRID 1958360Notes

Reaction equation

HRID 1958360 reaction equation
[N:1]1([C:5]([C:7]2[CH:8]=[N:9][N:10]([CH3:15])[C:11]=2[C:12]([OH:14])=O)=[O:6])[CH2:4][CH2:3][CH2:2]1.[NH2:16][C:17]1[N:22]=[CH:21][N:20]2[CH:23]=[C:24]([C:26]3[CH:27]=[C:28]([O:32][C:33](=[O:35])[CH3:34])[CH:29]=[CH:30][CH:31]=3)[N:25]=[C:19]2[CH:18]=1>>[C:33]([O:32][C:28]1[CH:29]=[CH:30][CH:31]=[C:26]([C:24]2[N:25]=[C:21]3[N:22]=[C:17]([NH:16][C:12]([C:11]4[N:10]([CH3:15])[N:9]=[CH:8][C:7]=4[C:5]([N:1]4[CH2:2][CH2:3][CH2:4]4)=[O:6])=[O:14])[CH:18]=[CH:19][N:20]3[CH:23]=2)[CH:27]=1)(=[O:35])[CH3:34]

Participants

3

Reactant 2

HCID 58446922HCID 58446922, compoundHCID 67392229HCID 67392229, compound

Product 1

HCID 53468647HCID 53468647, compound

Procedure

The title compound was prepared in analogy to example 82, step 3, from 4-(azetidine-1-carbonyl)-1-methyl-1H-pyrazole-5-carboxylic acid (156 mg, 746 μmol) and acetic acid 3-(7-amino-imidazo[1,2-c]pyrimidin-2-yl)-phenyl ester (200 mg, 746 μmol). Yield: 158 mg (42%). Yellow foam. MS (m/z)=459.2 [M+H+].

Sources & evidence

ORD record
ord-87b2f3203b4e45738f730537c74d7275
Source dataset
uspto-grants-2013_04
Patent number
US08410117B2

Reaction notes

Loading…