反应详情

温度

0 °C

A solution of ethyl 6-(2-(tert-butoxycarbonyl-(isopropyl)amino)thiazol-5-yl)-8-phenylimidazo[1,2-a]pyridine-2-carboxylate (100 mg, 0.2 mmol) in ether was cooled in an ice bath and treated with solid LAH (15 mg, 0.4 mmol). The mixture was stirred at 0° C. for 2 hours. The reaction was quenched with water, diluted with ethyl acetate and washed with water, brine and concentrated to give tert-butyl 5-(2-(hydroxymethyl)-8-phenylimidazo[1,2-a]pyridin-6-yl)thiazol-2-yl(isopropyl)carbamate. LCMS (Conditions C): 3.36 min (RT); (M+H)+=465.32 (100%).

1. customThe reaction was quenched with water
2. additiondiluted with ethyl acetate
3. washwashed with water, brine
4. concentrationconcentrated