Chloroacetaldehyde → HCID 58207922, compound

HRID 1958494Notes

Reaction equation

HRID 1958494 reaction equation
[NH2:1][C:2]1[N:3]=[CH:4][C:5]([C:14]2[S:15][C:16]([N:19]([CH:27]([CH3:29])[CH3:28])[C:20](=[O:26])[O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[CH:17][N:18]=2)=[N:6][C:7]=1[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.Cl[CH2:31][CH:32]=O>CCO>[CH:27]([N:19]([C:16]1[S:15][C:14]([C:5]2[N:6]=[C:7]([C:8]3[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=3)[C:2]3[N:3]([CH:31]=[CH:32][N:1]=3)[CH:4]=2)=[N:18][CH:17]=1)[C:20](=[O:26])[O:21][C:22]([CH3:23])([CH3:24])[CH3:25])([CH3:29])[CH3:28]

Participants

4

Reactant 2

HCID 33ChloroacetaldehydeHCID 58207883HCID 58207883, compound

Product 1

HCID 58207922HCID 58207922, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
60 °C

Procedure

A solution of tert-butyl 2-(5-amino-6-phenylpyrazin-2-yl)thiazol-5-yl(isopropyl)carbamate (23.7 mg, 0.06 mmol) in EtOH (0.25 mL) was added chloroacetaldehyde (11.8 μL, 50% in water) and the reaction mixture was then heated to 60° C. for 24 h and then concentrated to dryness. The crude product was dried under high vacuum and used without further purification.

Workup

  1. concentrationconcentrated to dryness
  2. dry with materialThe crude product was dried under high vacuum
  3. customused without further purification

Sources & evidence

ORD record
ord-8d8a49d63267436786724837470ea9d4
Source dataset
uspto-grants-2013_04
Patent number
US08410128B2

Reaction notes

Loading…