5-Bromo-2-isobutyl-1,3-thiazole → HCID 58207904, compound

HRID 1958501Notes

Reaction equation

HRID 1958501 reaction equation
Br[C:2]1[S:6][C:5]([CH2:7][CH:8]([CH3:10])[CH3:9])=[N:4][CH:3]=1.[C:11]1([CH3:29])[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[C:17]1[C:18]2[N:19]([CH:26]=[CH:27][N:28]=2)[CH:20]=[C:21](B(O)O)[CH:22]=1>>[CH2:7]([C:5]1[S:6][C:2]([C:21]2[CH:22]=[C:17]([C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=3[CH3:29])[C:18]3[N:19]([CH:26]=[CH:27][N:28]=3)[CH:20]=2)=[CH:3][N:4]=1)[CH:8]([CH3:10])[CH3:9]

Participants

3

Reactant 2

HCID 206967745-Bromo-2-isobutyl-1,3-thiazoleHCID 67008224HCID 67008224, compound

Product 1

HCID 58207904HCID 58207904, compound

Procedure

Example 189 was prepared using the procedure describe for Example 34, step 4, from 5-bromo-2-isobutylthiazole and 8-o-tolylimidazo[1,2-a]pyridin-6-ylboronic acid. LCMS (Conditions C): Tr 2.86 min.; (M+H)+: 348.0

Workup

  1. customExample 189 was prepared
  2. customTr 2.86 min.

Sources & evidence

ORD record
ord-2d6a382fec494bea98e9c37bef41469e
Source dataset
uspto-grants-2013_04
Patent number
US08410128B2

Reaction notes

Loading…