HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1958614Generated: November 2, 2026
Sodium Carbonate → 2,2,2-Trifluoro-1-(3'-methylbiphenyl-2-yl)ethanol
https://huagongshe.com/reaction/1958614
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 2-Oxopropiononitrile | HCID 69430 | — |
| Reactant | 3-Tolylboronic acid | HCID 2733950 | — |
| Reactant | 1-(4-Bromophenyl)-2,2,2-trifluoroethanol | HCID 11219024 | — |
| Catalyst | HCID 178418476 | HCID 178418476 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2,2,2-Trifluoro-1-(3'-methylbiphenyl-2-yl)ethanol | HCID 66649251 | 79% |
Reaction Steps
Alternatively, 1-(4-bromophenyl)-2,2,2-trifluoroethanol (0.98 g, 3.86 mmol), m-tolylboronic acid (0.63 g, 4.63 mmol), Pd(PPh3)2Cl2 (0.16 g, 0.232 mmol Pd), Na2CO3 (0.90 g, 8.49 mmol), AcCN (10 mls), and H2O (10 mls) were combined and heated in the microwave at 150° C. for 10 minutes. The reaction was shown complete by TLC (CH2Cl2). The mixture was cooled, concentrated, slurried in CH2Cl2, filtered, and chromatographed over silica gel (CH2Cl2) to give 0.80 g of 2,2,2-trifluoro-1-(3′-methylbiphenyl-2-yl)ethanol. Yield: 79%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08410121B2 |
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| Source dataset | uspto-grants-2013_04 |
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| ORD ID | ord-a7db43f6b1b94f30899feb9f4b1789b5 |
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| Source note | uspto-grants-2013_04 |
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