HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 1-Benzyl 3-methyl azetidine-1,3-dicarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Benzyl chloroformate | HCID 10387 | — |
| Reactant | Methyl azetidine-3-carboxylate hydrochloride | HCID 21100040 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-Benzyl 3-methyl azetidine-1,3-dicarboxylate | HCID 45072502 | — |
Reaction Steps
10 g of azetidine-3-carboxylic methyl ester hydrochloride and then 23 ml of triethylamine are added to 150 ml of CH2Cl2. The mixture is cooled and 13.5 g of benzyl chloroformate are added. After leaving overnight at AT, washing is carried out with water and then with HCl (N). After drying, concentrating to dryness and purifying by chromatography on silica (eluent: heptane-AcOEt (gradient from 0% to 50%)), 13.1 g of the expected compound are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08410137B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-5fd37fb0346845d19ef9c506ffa14fb7 |
| Source note | uspto-grants-2013_04 |