HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → HCID 67299283, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Boron tribromide | HCID 25134 | — |
| Reactant | HCID 67299510 | HCID 67299510 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 67299283 | HCID 67299283 | — |
Reaction Steps
5 g of the compound obtained in stage 23D) are added to 100 ml of CH2Cl2, cooling is carried out at −50° C. and 41.8 ml of 1M solution of BBr3 in CH2Cl2 are added. The temperature is allowed to return to 20° C. and then 20 ml of methanol are added. The mixture is concentrated to dryness and the residue is taken up in CH2Cl2, washed with water, dried over MgSO4 and concentrated to dryness. After purifying by chromatography on silica (heptane up to heptane/AcOEt 75/25), 4.57 g of the expected compound are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08410137B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-22819568d684401a83f3fcb35a66733a |
| Source note | uspto-grants-2013_04 |