Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-(3-Bromopropoxy)tetrahydro-2H-pyran | HCID 2777988 | — |
| Reactant | HCID 67299283 | HCID 67299283 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | HCID 67299426 | HCID 67299426 | 95.4% |
Reaction Steps
2.3 g of the compound obtained in stage 23E), 1.95 g of 2-(3-bromopropoxy)tetrahydro-2H-pyran and 1.2 g of potassium carbonate are added to 15 ml of DMF and then the mixture is heated at 60° C. for 7 hours. It is poured onto ice-cold water, extraction is carried out with ether and the extract is dried and concentrated to dryness. After purifying by chromatography on silica (heptane and then heptane/AcOEt 80/20), 3.1 g of the expected compound are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08410137B2 |
|---|
| Source dataset | uspto-grants-2013_04 |
|---|
| ORD ID | ord-16fb7003e94e4fffb7d9cfa445afb3d1 |
|---|
| Source note | uspto-grants-2013_04 |
|---|
