2,3,4-Trifluorophenyl isocyanate → (R)-3-Carboxy-N,N,N-trimethyl-2-(3-(2,3,4-trifluorophenyl)ureido)-propan-1-aminium acetate

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Reaction Steps

According to the method described in example S11, aminocarnitine (41 mg) was reacted with 1,2,3-trifluoro-4-isocyanatobenzene to yield the title compound as a white solid (2.3 mg). 1H NMR (400 MHz, CD3OD): δ=7.70-7.60 (m, 1H), 7.10-7.00 (m, 1H), 4.61 (br s, 1H), 3.80-45 (m, 2H), 3.22 (s, 9H), 2.40-2.60 (m, 2H), 1.97 (s, 3H); MS ESI [M+H]+, calcd for [C14H18F3N3O3+H]+ 334.3 found m/z 334.1 (100)

Provenance & Evidence