HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(2-Pyridyl)thiophene-2-sulfonyl chloride → (R)-benzyl 4-(dimethylamino)-3-(5-(pyridin-2-yl)thiophene-2-sulfonamido)butanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(2-Pyridyl)thiophene-2-sulfonyl chloride | HCID 2737231 | — |
| Reactant | (R)-benzyl 3-amino-4-(dimethylamino)butanoate | HCID 46223508 | — |
| Product | (R)-benzyl 4-(dimethylamino)-3-(5-(pyridin-2-yl)thiophene-2-sulfonamido)butanoate | HCID 86641217 | 40% |
Reaction Steps
According to the method described in example S20a, (R)-benzyl 3-amino-4-(dimethylamino)butanoate (27 mg, 0.086 mmol) was reacted with 5-(pyridin-2-yl)thiophene-2-sulfonyl chloride to yield the title compound as a white solid (16 mg, 40%). MS ESI 460.2 [M+H]+, calcd for [C22H25N3O4S2+H]+ 460.13
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08410150B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-35fdec3179e54deeb5441cc3401fb14a |
| Source note | uspto-grants-2013_04 |