Methyl iodide → (R)-4-(benzyloxy)-N,N,N-trimethyl-4-oxo-2-(4-pentylphenylsulfonamido)butan-1-aminium iodide

HRID 1958722Notes

Reaction equation

HRID 1958722 reaction equation
[CH3:1][N:2]([CH3:31])[CH2:3][C@H:4]([NH:16][S:17]([C:20]1[CH:25]=[CH:24][C:23]([CH2:26][CH2:27][CH2:28][CH2:29][CH3:30])=[CH:22][CH:21]=1)(=[O:19])=[O:18])[CH2:5][C:6]([O:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[O:7].[CH3:32][I:33]>>[I-:33].[CH2:9]([O:8][C:6](=[O:7])[CH2:5][C@@H:4]([NH:16][S:17]([C:20]1[CH:21]=[CH:22][C:23]([CH2:26][CH2:27][CH2:28][CH2:29][CH3:30])=[CH:24][CH:25]=1)(=[O:19])=[O:18])[CH2:3][N+:2]([CH3:32])([CH3:1])[CH3:31])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 86641219(R)-benzyl 4-(dimethylamino)-3-(4-pentylphenylsulfonamido)butanoate

Product 1

HCID 68744070(R)-4-(benzyloxy)-N,N,N-trimethyl-4-oxo-2-(4-pentylphenylsulfonamido)butan-1-aminium iodide

Procedure

According to the method described in example S20b, (R)-benzyl 4-(dimethylamino)-3-(4-pentylphenylsulfonamido)butanoate was reacted with methyl iodide to give the title compound as a white solid in quantitative yield.

Sources & evidence

ORD record
ord-0a23351b14c44b1f91107312943f6011
Source dataset
uspto-grants-2013_04
Patent number
US08410150B2

Reaction notes

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