HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1958724Generated: October 31, 2026
Methyl triflate → (R)-1-(N-(4-methoxy-4-oxo-1-(trimethylammonio)butan-2-yl)sulfamoyl)-3-methyl-1H-imidazol-3-ium chloride trifluoromethanesulfonate
https://huagongshe.com/reaction/1958724
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methyl triflate | HCID 9526 | — |
| Reactant | (R)-2-(1H-imidazole-1-sulfonamido)-4-methoxy-N,N,N-trimethyl-4-oxobutan-1-aminium chloride | HCID 68743870 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (R)-1-(N-(4-methoxy-4-oxo-1-(trimethylammonio)butan-2-yl)sulfamoyl)-3-methyl-1H-imidazol-3-ium chloride trifluoromethanesulfonate | HCID 86641221 | — |
Reaction Steps
To a solution of (R)-2-(1H-imidazole-1-sulfonamido)-4-methoxy-N,N,N-trimethyl-4-oxobutan-1-aminium chloride in DCM (5 mL), cooled at 0° C., is added methyl triflate (1.05 equiv). After being stirring for 2 h at 0° C., the reaction mixture is concentrated under reduced pressure to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08410150B2 |
|---|
| Source dataset | uspto-grants-2013_04 |
|---|
| ORD ID | ord-5cb816ebd8884cad9745f01d4a5d8b7f |
|---|
| Source note | uspto-grants-2013_04 |
|---|
