HCID 25064252, compound → HCID 25064256, compound

Participants

Reaction Steps

(R)-3-(5-(phenylethynyl)thiophene-2-carboxamido)-4-(trimethylammonio)-butanoate (15 mg, 0.04 mmol) was dissolved into MeOH (3 mL). The solution was purged with nitrogen and 10% palladium on carbon (5 mg) was added. The vessel was purged with hydrogen and stirred for 1 h. The mixture was filtered through celite and solvents removed in vacuo to give the title compound (13 mg, 88%) as a white solid. 1H NMR (400 MHz, CD3OD) δ 7.51 (d, 1H, J=3.9 Hz), 7.27-7.23 (m, 2H), 7.19-7.14 (m, 3H), 6.81 (d, 1H, J=3.8 Hz), 4.85-4.77 (m, 1H), 3.72-3.58 (m, 2H), 3.22 (s, 9H), 3.16 (t, 2H, J=7.8 Hz), 2.98 (t, 2H, J=7.4 Hz), 2.59-2.48 (m, 2H); MS ESI 375.2 [M+H]+, calcd for [C20H26N2O3S+H]+ 375.2

Provenance & Evidence