HCID 68744388, compound → HCID 25064883, compound

Participants

Reaction Steps

(R)-3-(4-(phenylethynyl)benzamido)-4-(trimethylammonio)butanoate (10 mg, 0.027 mmol) was dissolved into MeOH (1 mL). The solution was treated with 10% Pd/C (0.5 mg). The mixture was stirred under hydrogen at room temperature overnight, and filtered through celite. MeOH was removed under vacuum. The residue was loaded onto a silica gel column and eluted with 4:1 MeOH/DCM to give the title compound as a white powder (2 mg, 22%). 1H NMR (400 MHz, D2O) δ 7.54 (d, 2H, J=8 Hz), 7.22-7.18 (m, 4H), 7.13-7.10 (m, 3H), 4.87-4.81 (m, 1H), 3.65-3.59 (m, 1H), 3.70 (d, 1H, J=13.2 Hz), 3.10 (s, 9H), 2.92-2.85 (m, 4H), 2.46 (d, 2H, J=6.8 Hz); MS ESI 369.2 [M+H]+, calcd for [C22H28N2O3+H]+ 369.22.

Provenance & Evidence