Methyl iodide → HCID 68742722, compound

HRID 1958734Notes

Reaction equation

[CH3:1][N:2]([CH3:38])[CH2:3][C@H:4]([NH:16][S:17]([C:20]1[CH:25]=[CH:24][C:23]([NH:26][C:27]([O:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH3:37])=[O:28])=[CH:22][CH:21]=1)(=[O:19])=[O:18])[CH2:5][C:6]([O:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[O:7].[CH3:39][I:40]>>[I-:40].[CH2:9]([O:8][C:6](=[O:7])[CH2:5][C@@H:4]([NH:16][S:17]([C:20]1[CH:25]=[CH:24][C:23]([NH:26][C:27]([O:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH3:37])=[O:28])=[CH:22][CH:21]=1)(=[O:18])=[O:19])[CH2:3][N+:2]([CH3:39])([CH3:1])[CH3:38])[C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 86641227HCID 86641227, compound

Product 1

HCID 68742722HCID 68742722, compound

Procedure

According to the method described in example S72b, (R)-benzyl 4-(dimethylamino)-3-(4-(octyloxycarbonylamino)phenylsulfonamido)butanoate was reacted with methyl iodide to give the title compound as a white solid in quantitative yield. MS ESI 563.3 [M]+, calcd for [C29H44N3O6S+] 562.74

Sources & evidence

ORD record: ord-2a5bee964a154fec84b67fdf575ca594
Source dataset: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08410150B2

Reaction notes

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