HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Ethoxy-3-(morpholine-4-carboxamido)benzene-1-sulfonyl chloride → (R)-benzyl 4-(dimethylamino)-3-(4-ethoxy-3-(morpholine-4-carboxamido)phenyl-sulfonamido)butanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Ethoxy-3-(morpholine-4-carboxamido)benzene-1-sulfonyl chloride | HCID 2758760 | — |
| Reactant | (R)-benzyl 3-amino-4-(dimethylamino)butanoate | HCID 46223508 | — |
| Product | (R)-benzyl 4-(dimethylamino)-3-(4-ethoxy-3-(morpholine-4-carboxamido)phenyl-sulfonamido)butanoate | HCID 86641228 | 68% |
Reaction Steps
According to the method described in example S72a, (R)-benzyl 3-amino-4-(dimethylamino)butanoate (30 mg, 0.086 mmol) was reacted with 4-ethoxy-3-(morpholine-4-carboxamido)benzene-1-sulfonyl chloride to yield the title compound as a white solid (32 mg, 68%). MS ESI 549.3 [M+H]+, calcd for [C26H36N4O7S+H]+ 549.23
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08410150B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-6dadd6ba4e0d4eddacf8c62886fd767a |
| Source note | uspto-grants-2013_04 |