HCID 68741254, compound → HCID 68741878, compound

Participants

Reaction Steps

A solution of (R)-3-carboxy-N,N,N-trimethyl-2-(5-(m-tolylethynyl)thiophene-2-sulfonamido)propan-1-aminium 2,2,2-trifluoroacetate (7 mg, 0.013 mmol) in MeOH (3 mL) was purged with nitrogen and Pd/C (10 mg) was added and the flask was purged with hydrogen and stirred for 1 h. The mixture was filtered through celite and concentrated. The residue was dissolved into H2O and lyophilized to give the title compound as a white solid (7 mg, 100%). 1H NMR (400 MHz, D2O) δ 7.42 (d, 1H, J=3.8 Hz), 7.08 (t, 1H, J=7.4 Hz), 6.97-6.94 (m, 2H), 6.88 (d, 1H, J=7.1 Hz), 6.74 (d, 1H, J=3.9 Hz) 4.14-4.11 (m, 1H), 3.52-3.49 (m, 1H), 3.46-3.44 (m, 1H), 3.15-3.07 (m, 2H), 3.10 (s, 9H), 2.84 (m, 2H) 2.32-2.25 (m, 1H) 2.15 (s, 3H), 2.01-1.96 (m, 1H); MS ESI 425.2 [M+H]+, calcd for [C20H29N2O4S2+H]+ 425.16.

Provenance & Evidence