Methyl iodide → HCID 68743092, compound

HRID 1958743Notes

Reaction equation

[CH3:1][N:2]([CH3:33])[CH2:3][C@H:4]([NH:16][S:17]([C:20]1[S:21][C:22]([C:25]#[C:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)=[CH:23][CH:24]=1)(=[O:19])=[O:18])[CH2:5][C:6]([O:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[O:7].[CH3:34][I:35]>>[I-:35].[CH2:9]([O:8][C:6](=[O:7])[CH2:5][C@@H:4]([NH:16][S:17]([C:20]1[S:21][C:22]([C:25]#[C:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)=[CH:23][CH:24]=1)(=[O:19])=[O:18])[CH2:3][N+:2]([CH3:34])([CH3:1])[CH3:33])[C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 86641231HCID 86641231, compound

Product 1

HCID 68743092HCID 68743092, compound

Procedure

According to the method described in example S76b, (R)-benzyl 4-(dimethylamino)-3-(5-(phenylethynyl)thiophene-2-sulfonamido)butanoate was reacted with methyl iodide to give the title compound as a yellow solid (quantitative). ESI 497.3 [M]+, calcd for [C26H29N2O4S2]+ 497.16.

Sources & evidence

ORD record: ord-f6cbc6ed45264fe08dc49e09276d19fa
Source dataset: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08410150B2

Reaction notes

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