Nicotinic Acid → HCID 25066340, compound

Participants

Reaction Steps

According to the method described in example S115, (R)-3-(5-bromofuran-2-carboxamido)-4-(trimethylammonio)butanoate was reacted with 1-ethynyl-3-(hexyloxy)benzene. The crude product was purified by silica gel chromatography (CH2Cl2/MeOH 3:2) to give the title compound as a white powder (11.1 mg, 20%). 1H NMR (400 MHz, D2O) δ 6.94-6.89 (m, 2H), 6.81-6.79 (m, 1H), 6.57 (s, 1H), 6.46-6.44 (m, 1H), 6.30 (s, 1H), 4.80-4.76 (m, 1H), 3.67-3.45 (m, 4H), 3.01 (s, 9H), 2.44-2.35 (m, 2H), 1.38-1.32 (m, 2H), 1.10-0.95 (m, 6H), 0.61 (t, 3H, J=6.4 Hz); MS ESI [M+H]+, calcd for [C26H34N2O5+H]+ 455.25; found m/z 455.3.

Provenance & Evidence