HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-Solketal → (R)-3-Chloro-4-(2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)-N-hydroxy-5-methyl-benzamidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-Solketal | HCID 736056 | — |
| Reactant | 3-Chloro-4-hydroxy-5-methylbenzonitrile | HCID 19038348 | — |
| Reactant | HCID 178426655 | HCID 178426655 | — |
| Product | (R)-3-Chloro-4-(2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)-N-hydroxy-5-methyl-benzamidine | HCID 178426667 | — |
Reaction Steps
The title compound is obtained as a colorless oil (1.39 g) in analogy to rac-4-(2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)-N-hydroxy-3,5-dimethyl-benzamidine starting from 3-chloro-4-hydroxy-5-methyl-benzonitrile and L-α,β-isopropylidene glycerol. LC-MS: tR=0.66 min, [M+H]+=314.96.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08410151B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-7aaba0f690754c1190f302aea1e5a095 |
| Source note | uspto-grants-2013_04 |