4-Hydroxy-2-methylbenzonitrile → HCID 178429065, compound

HRID 1958788Notes

Reaction equation

HRID 1958788 reaction equation
C([C:3]1[CH:18]=[C:17]([C:19](=[NH:22])[NH:20][OH:21])[CH:16]=[C:15](C)[C:4]=1[O:5][CH2:6][C@@H:7]([OH:14])[CH2:8][NH:9][C:10](=[O:13])[CH2:11][OH:12])C.O[C:25]1C=CC(C#N)=C(C)C=1>>[OH:12][CH2:11][C:10]([NH:9][CH2:8][C@H:7]([OH:14])[CH2:6][O:5][C:4]1[CH:3]=[CH:18][C:17]([C:19](=[NH:22])[NH:20][OH:21])=[C:16]([CH3:25])[CH:15]=1)=[O:13]

Participants

3

Reactant 2

HCID 3087414-Hydroxy-2-methylbenzonitrileHCID 178436630HCID 178436630, compound

Product 1

HCID 178429065HCID 178429065, compound

Procedure

The title compound is obtained as a beige oil (1.0 g) in analogy to N—((S)-3-[2-ethyl-4-(N-hydroxycarbamimidoyl)-6-methyl-phenoxy]-2-hydroxy-propyl)-2-hydroxy-acetamide starting from 4-hydroxy-2-methyl-benzonitrile. LC-MS: tR=0.35 min, [M+H]+=297.99.

Sources & evidence

ORD record
ord-fd4aea521dac4003928acf6e16453e00
Source dataset
uspto-grants-2013_04
Patent number
US08410151B2

Reaction notes

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