HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 19588Generated: October 30, 2026
Hydrochloric Acid → Methyl 5-isopropyl-4-nitropyrazol-3-carboxylate
https://huagongshe.com/reaction/19588
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methanol | HCID 887 | — |
| Reactant | 4-nitro-5-(propan-2-yl)-1H-pyrazole-3-carboxylic acid | HCID 12150601 | — |
| Product | Methyl 5-isopropyl-4-nitropyrazol-3-carboxylate | HCID 12150602 | 91% |
Reaction Steps
5-Isopropyl-4-nitropyrazole-3-carboxylic acid was added to a 4.5M solution of HCl in absolute methanol. The reaction mixture was heated at 60° C. for 7 hours. The title compound was crystallized from ethyl acetate; yield 91%; mp=78-80° C. 1H NMR (300 MHz, CDCl3): 1.39 d (6H, J=7.1 Hz); 3.64 sept (1H, J=7.1 Hz), 3.98 s (3H). CHN required: C=45.07%; H=5.20%; N=19.70%; found: C=45.21%; H=5.23%; N=19.65%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07745450B2 |
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| Source dataset | uspto-grants-2010_06 |
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| ORD ID | ord-99e2a19f95d54763b54daf0156cff5bb |
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| Source note | uspto-grants-2010_06 |
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